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Zhang N, Zeng W, Du T, Wei H, Tian W, Meng Y, He G, Lei A, Zhu C (2023) Lacticaseibacillus casei CNRZ1874 supplementation promotes M1 alveolar macrophage activation and attenuates Mycoplasma pneumoniae pneumonia

[3] The proposed mechanism involves B12 altering the gene expression of skin bacteria ( Cutibacterium acnes ), leading to increased inflammatory compounds

doi: 10.1038/s41419-021-04184-8 155 YangSLinCZhuoXWangJRaoSXuWet al

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Another approach of TNF- pathway blockade that has been recently examined is the development of orally active small molecules (such as UCB-9260) that destabilize TNF- trimer, impeding TNF--TNFR1 binding and signaling [200]